Research Articles

YearAuthorsTitleDOI
2021Long, B., Verma, V., Ryan, K.M., Padrela, L.Generation and physicochemical characterization of posaconazole cocrystals using Gas Antisolvent (GAS) and Supercritical Solvent (CSS) methods10.1016/j.supflu.2020.105134
2021Verma, V., Ryan, K.M., Padrela, L.Pharmaceutical nanoparticle isolation using CO2-assisted dynamic bed coating10.1016/j.ijpharm.2020.120032
2020Verma, V., Bordignon, S., Chierotti, M.R., Lestari, M., Lyons, K., Padrela, L., Ryan, K.M., Lusi, M.Cortisone and cortisol break hydrogen-bonding rules to make a drug-prodrug solid solution10.1107/S2052252520013263
2020Soto, R., Svärd, M., Verma, V., Padrela, L., Ryan, K., Rasmuson, Å.C.Solubility and thermodynamic analysis of ketoprofen in organic solvents10.1016/j.ijpharm.2020.119686
2020Muthancheri, I., Long, B., Ryan, K.M., Padrela, L., Ramachandran, R.Development and validation of a two-dimensional population balance model for a supercritical CO2 antisolvent batch crystallization process10.1016/j.apt.2020.06.008
2020Long, B., Ryan, K.M., Padrela, L.Investigating Process Variables and Additive Selection to Optimize Polymorphic Control of Carbamazepine in a CO2Antisolvent Crystallization Process10.1021/acs.oprd.9b00545
2020Ziaee, A., Albadarin, A.B., Padrela, L., Ung, M.-T., Femmer, T., Walker, G., O’Reilly, E.A rational approach towards spray drying of biopharmaceuticals: The case of lysozyme10.1016/j.powtec.2020.02.057
2019Ziaee, A., O’Dea, S., Howard-Hildige, A., Padrela, L., Potter, C., Iqbal, J., Albadarin, A.B., Walker, G., O’Reilly, E.J.Amorphous solid dispersion of ibuprofen: A comparative study on the effect of solution based techniques10.1016/j.ijpharm.2019.118816
2019Long, B., Ryan, K.M., Padrela, L.From batch to continuous — New opportunities for supercritical CO2 technology in pharmaceutical manufacturing10.1016/j.ejps.2019.104971
2019Long, B., Walker, G.M., Ryan, K.M., Padrela, L.Controlling Polymorphism of Carbamazepine Nanoparticles in a Continuous Supercritical-CO2-Assisted Spray Drying Process10.1021/acs.cgd.9b00154
2019Padrela, L., Zeglinski, J., Ryan, K.Unraveling the Link between Solvent-Mediated Proton Transfer and the Salt Formation of Saccharin and Sulfamethazine10.1021/acs.cgd.8b01015
2019Ziaee, A., Albadarin, A.B., Padrela, L., Femmer, T., O’Reilly, E., Walker, G.Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches10.1016/j.ejps.2018.10.026
2019Padrela, L.M., Castro-Dominguez, B., Ziaee, A., Long, B., Ryan, K.M., Walker, G., O’Reilly, E.J.Co-crystal polymorphic control by nanodroplet and electrical confinement10.1039/c9ce00060g
2018Karimi-Jafari, M., Padrela, L., Walker, G.M., Croker, D.M.Creating cocrystals: A review of pharmaceutical cocrystal preparation routes and applications10.1021/acs.cgd.8b00933
2018Padrela, L., Rodrigues, M.A., Duarte, A., Dias, A.M.A., Braga, M.E.M., de Sousa, H.C.Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review10.1016/j.addr.2018.07.010
2017Ziaee, A., Albadarin, A.B., Padrela, L., Faucher, A., O’Reilly, E., Walker, G.Spray drying ternary amorphous solid dispersions of ibuprofen – An investigation into critical formulation and processing parameters10.1016/j.ejpb.2017.08.005
2017Padrela, L., Zeglinski, J., Ryan, K.M.Insight into the Role of Additives in Controlling Polymorphic Outcome: A CO2-Antisolvent Crystallization Process of Carbamazepine10.1021/acs.cgd.7b00163
2015Padrela, L., Rodrigues, M.A., Tiago, J., Velaga, S.P., Matos, H.A., Azevedo, E.G.D.Insight into the Mechanisms of Cocrystallization of Pharmaceuticals in Supercritical Solvents10.1021/acs.cgd.5b00200
2014Padrela, L., Rodrigues, M.A., Tiago, J., Velaga, S.P., Matos, H.A., Azevedo, E.G.D.Tuning physicochemical properties of theophylline by cocrystallization using the supercritical fluid enhanced atomization technique10.1016/j.supflu.2013.12.011
2014Rodrigues, M.A., Tiago, J.M., Padrela, L., Matos, H.A., Nunes, T.G., Pinheiro, L., Almeida, A.J., De Azevedo, E.G.New thermoresistant polymorph from CO2 recrystallization of minocycline hydrochloride10.1007/s11095-014-1406-3
2013Tiago, J.M., Padrela, L., Rodrigues, M.A., Matos, H.A., Almeida, A.J., De Azevedo, E.G.Single-step co-crystallization and lipid dispersion by supercritical enhanced atomization10.1021/cg401131x
2012Rodrigues, M.A., Figueiredo, L., Padrela, L., Cadete, A., Tiago, J., Matos, H.A., Azevedo, E.G.D., Florindo, H.F., Gonçalves, L.M.D., Almeida, A.J.Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model10.1016/j.ejpb.2012.07.005
2012Padrela, L., De Azevedo, E.G., Velaga, S.P.Powder X-ray diffraction method for the quantification of cocrystals in the crystallization mixture10.3109/03639045.2011.633263
2011Rodrigues, M.A., Padrela, L., Geraldes, V., Santos, J., Matos, H.A., Azevedo, E.G.Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions10.1016/j.supflu.2011.05.012
2010Padrela, L., Rodrigues, M.A., Velaga, S.P., Fernandes, A.C., Matos, H.A., de Azevedo, E.G.Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process10.1016/j.supflu.2010.01.010
2010Pinheiro, L., Matos, A., Crespo, J., Padrela, L., Rodrigues, M.A., Matos, H.A., Castro, M., Durte, A., Almeida, A.J., Bettencourt, A.Antibacterial activity of tigecycline micro/nanoparticles under supercritical fluids conditionsN/A
2009Padrela, L., Rodrigues, M.A., Velaga, S.P., Matos, H.A., de Azevedo, E.G.Formation of indomethacin-saccharin cocrystals using supercritical fluid technology10.1016/j.ejps.2009.05.010
2009Rodrigues, M.A., Li, J., Padrela, L., Almeida, A., Matos, H.A., de Azevedo, E.G.Anti-solvent effect in the production of lysozyme nanoparticles by supercritical fluid-assisted atomization processes10.1016/j.supflu.2008.06.006

Patents

Year AuthorsTitlePatent
2015Duarte, I., Pereira, M.J., Padrela, L., Temtem, M.Synthesis and particle engineering of cocrystalsEP3046546A1
2013Rodrigues, M.A., Li, J., Padrela, L., , Matos, H.A., de Azevedo, E.G., L., Pinheiro, A.F., Bettencourt., M. Castro, A.J. Almeida, M.A.d.C DuarteCrystalline minocycline thermo-resistant obtained by recrystallization with carbon dioxideWO2013095169A1
2013Rodrigues, M.A., Li, J., Padrela, L., Almeida, A., Matos, H.A., de Azevedo, E.G., L. GoncalvesVaccine against strangles of the equidaeWO2013129953A1