Continuous Manufacturing of Pharmaceutical Nanoparticles (CM‐Nano) will provide continuous production and isolation of spray dried nanoparticles onto carrier particles to undergo direction compression. This technology aims to address the poor solubility; lack of Nano manufacturing technologies to provide accurate control over particle size and solid‐state; and pharmaceutical crystalline particles with the desired rheological properties in a continuous approach. Thus, providing novel, continuous, and scalable method to produce active pharmaceutical ingredient Nanoparticles with improved solubility and dissolution rate.