Title: Single-Step Nucleation, Crystallization and Formulation of Aqueous Crystal Injectable Nanosuspensions with Long-Acting Activity using Supercritical Antisolvent Assisted Spray Drying

The objective of this project is to generate data on the nucleation and crystal growth and molecular dynamic modelling of the selected class of active pharmaceutical ingredients (APIs) during batch and continuous supercritical antisolvent assisted spray drying for the generation of nanosuspensions.

Funding Body: European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement.
    • Selection of the optimal process conditions and excipients to obtain a specific polymorphic form and crystal size distribution. 
    • Single step production and isolation of nanoparticles from supercritical antisolvent assisted spray drying into aqueous nanosuspension. 
    • Control over the resultant polymorphic forms of the APIs.
    • Design of a long-acting (LA) stable suspension with appropriate release kinetics.
    • Perform molecular simulations (Density Functional Theory) on excipient/API interactions to guide in the selection of the optimal excipient to enhance nucleation and reduce subsequent particle growth and stabilise the desired resultant particle size distribution. 
Team members: Fidel Méndez, Luis Padrela (Lead PI), Robert Geertman (PI), Lidia Tajber (PI)